Single arm poster v2

Oncothermia survival studies are problematic due to the missing control arm. This is a problem is general, when the treatment targets advanced, mostly refractory, relapsed malignancies in high treatment lines, when the only way is the sequential treatment. Usually the care in high line treatment (or in terminal phase) has very limited evidence based possibilities, its medical decision-making processes are usually well tailored to the individual patients [18], [19]. In these cases evidences have to be shown when randomized controlled trials are not possible, [20]. The sequential trial [1], [2], [3], is well known, and applied frequently in the case of small trials [4]. The sequential trial (like the oncothermia) is applied for the same patient in sequences, In this approach the development of the patient is measured and documented. Our objective to show how the evaluation of the single-arm study could be realistic enough to be evidence based.